AsparPeg (PEG Asparaginase) is L-asparaginase (L-Amidohydrolase) that is covalently conjugated to monomethoxypolyethelene glycol (mPEG). L- Asparaginase is a tetrameric enzyme that is produced endogenously by E. coli and consists of identical 34.5 kDa subunits. Approximately 69 to 82 molecules of mPEG are linked to L-Asparaginase; the molecular weight of each mPEG molecule is about 5kDa. The mechanism of action of PEG Asparaginase is thought to be based on selective killing of leukemic cells due to depletion of plasma asparagine.
- Indicated as a component of multi agent chemotherapeutic regimen for the treatment of patients with Acute Lymphoblastic Leukemia who are hypersensitive to asparaginase.
- Store at 2°C to 8°C
- Protect from light
- Do not freeze or shake
24 months from the date of manufacture